We all Know who Kari is from her appearances on the show Mythbusters.

Byron is featured along with fellow Build Team members Tory Belleci and Grant Imahara and also assists as co-hosts for Adam Savage and Jamie Hyneman in testing the plausibility of various myths. She became involved in the show after persistently showing up at Hyneman's M5 Industries workshop in a desire to get hired at his company. On her first day as a paid employee, she was asked by Hyneman and MythBusters producer Peter Rees to help out with the "vacuum plane toilet" myth, and she was asked to model her buttocks for a cast. She was given a more prominent role in the show starting with its second season. Not having had a long history in show business, at first she found it hard to act naturally with this more visible position but gradually became more used to it.

During the second half of the 2009 season, Byron was on parental leave from the show; her place on MythBusters was temporarily^.occupied by Jessi Combs